A Visible‐Light‐Driven <i>O</i> ‐Glycosylation with Selenoglycosides Mediated by Chalcogen Bonding to Umemoto's Reagent

E Erik Alvarez Valenzuela (Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA) T Tiffany Duong V Vinayak Pradeep (Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA) X Xuxian He (Department of Chemistry and Physical Sciences Nicholls St. University 906 East 1st St. Thibodaux LA 70301 USA) J Jacob M. Dobson (Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA) S Semin Lee K Kenneth Lopata (Department of Chemistry) J Justin R. Ragains (Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA)

Abstract

Abstract The activation of chalcogenoglycosides for O ‐glycosylation typically involves strong electrophiles requiring low temperature. Herein, we demonstrate that visible‐light irradiation of selenoglycosides in the presence of Umemoto's reagent results in often high‐yielding O ‐glycosylation. We provide evidence that this process is mediated by a novel mode of reactivity, specifically photoinduced electron transfer within a chalcogen‐bonded complex.

Article Details

Volume / Issue Vol. 64, Issue 30
Published July 21, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (8)

E

Erik Alvarez Valenzuela

Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA

T

Tiffany Duong

V

Vinayak Pradeep

Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA

X

Xuxian He

Department of Chemistry and Physical Sciences Nicholls St. University 906 East 1st St. Thibodaux LA 70301 USA

J

Jacob M. Dobson

Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA

S

Semin Lee

K

Kenneth Lopata

Department of Chemistry

J

Justin R. Ragains

Department of Chemistry Louisiana State University 232 Choppin Hall Baton Rouge LA 70803 USA