A Type II CDK6 Degrader Enables Cellular Targeting beyond the Limits of Type II Inhibition

J Ji Hyeon Kim (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) C Caitlin E. Mills (Laboratory of Systems Pharmacology, Department of Systems Biology) Z Zuzanna Kozicka (Department of Medical Oncology) D Daniel C. Scott (Department of Structural Biology) C Cyrus Jin (Department of Cancer Biology) Z Zixuan Jiang (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) B Brendan G. Dwyer (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) Q Qixiang Geng (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) S Sean T. Toenjes (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) W Woong Sub Byun (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) D Dina ElHarouni (Department of Pathology) H Hongyu Li K Keith L. Ligon A Abby M. Thornhill (Department of Cancer Biology) H Hannah M. Jones (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) B Bryan A. Romero (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) S Stephen M. Hinshaw (Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine) B Benjamin L. Ebert (Department of Medical Oncology) B Brenda A. Schulman K Katherine A. Donovan E Eric S. Fischer N Nathanael S. Gray

Article Details

Volume / Issue Vol. 148, Issue 26
Published July 08, 2026
Pages 27951-27964
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (22)

J

Ji Hyeon Kim

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

C

Caitlin E. Mills

Laboratory of Systems Pharmacology, Department of Systems Biology

Z

Zuzanna Kozicka

Department of Medical Oncology

D

Daniel C. Scott

Department of Structural Biology

C

Cyrus Jin

Department of Cancer Biology

Z

Zixuan Jiang

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

B

Brendan G. Dwyer

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

Q

Qixiang Geng

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

S

Sean T. Toenjes

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

W

Woong Sub Byun

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

D

Dina ElHarouni

Department of Pathology

H

Hongyu Li

K

Keith L. Ligon

A

Abby M. Thornhill

Department of Cancer Biology

H

Hannah M. Jones

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

B

Bryan A. Romero

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

S

Stephen M. Hinshaw

Department of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine

B

Benjamin L. Ebert

Department of Medical Oncology

B

Brenda A. Schulman

K

Katherine A. Donovan

E

Eric S. Fischer

N

Nathanael S. Gray