A Synergistic 3D‐Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer
Abstract
Abstract Interventional thermal therapy, such as radiofrequency ablation (RFA), is a preferred therapy for non‐small cell lung cancer (NSCLC) patients. However, part of some patients will still suffer from tumor recurrence due to incomplete ablation (e.g., restricted thermal conductivity, etc.). Notably, RFA can evoke anti‐tumor immunity by releasing tumor‐associated antigens (TAAs), but this effect is weak. Herein, to boost thermal and immune therapeutic efficiency for complete tumor eradication, an effective nano‐adjuvant (CpG‐pIL12‐LDHs, LC12), layered double hydroxides (LDHs) carrying immune stimulators, CpG ODN (CpG) and IL‐12 plasmid (pIL‐12), is developed, which is further integrated into a 3D‐printed collar for eliciting potent thermotherapy and therapeutic vaccine against lung cancer. The as‐prepared 3D‐printed adjuvant collar (3D‐LC12) can be attached to the RFA electronic needle and respond to the radiofrequency electrical field during treatment, enhancing ablation temperature, area, and nano‐adjuvant's diffusion. After release from the temperature‐sensitive collar, LC12 can form an in situ therapeutic cancer vaccine, activate APCs, and remodel the tumor microenvironment (TME), triggering a robust antitumor immune response. Therefore, the current study demonstrates a multi‐functional 3D‐printed adjuvant collar for efficient eradication of lung cancer via one‐time RFA‐integrated therapy, providing a novel combined strategy for interventional thermal therapy against tumors.
Article Details
Authors (14)
Weiyu Chen
Yuan Wu
Jianhua Luo
Department of Respiratory and Critical Care Medicine Center for Oncology Medicine the Fourth Affiliated Hospital of School of Medicine and International School of Medicine International Institutes of Medicine Zhejiang University Yiwu 322000 China
Wei Wei
Qitao Hu
Department of Respiratory Medicine Taizhou Municipal Hospital Taizhou Zhejiang 318000 China
Yiming Xu
Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University
Xinjie Zheng
Department of Respiratory and Critical Care Medicine Center for Oncology Medicine the Fourth Affiliated Hospital of School of Medicine and International School of Medicine International Institutes of Medicine Zhejiang University Yiwu 322000 China
Zhouyi Sun
Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine Yiwu 322000 China
Lingge Yang
Department of Respiratory and Critical Care Medicine Center for Oncology Medicine the Fourth Affiliated Hospital of School of Medicine and International School of Medicine International Institutes of Medicine Zhejiang University Yiwu 322000 China
Junkang Ding
Department of Respiratory Medicine Taizhou Municipal Hospital Taizhou Zhejiang 318000 China
Liyun Xu
Department of Respiratory and Critical Care Medicine Center for Oncology Medicine the Fourth Affiliated Hospital of School of Medicine and International School of Medicine International Institutes of Medicine Zhejiang University Yiwu 322000 China
Shugao Han
Department of Surgery The Second Affiliated Hospital, Zhejiang University School of Medicine Yiwu 322000 China
Weibo Cai
Departments of Radiology and Medical Physics University of Wisconsin‐Madison Madison WI 53705 USA
Kai Wang