A Sonosensitive Heterometallic Polyoxometalate for Highly Efficient Chemo‐Sonodynamic Synergistic Cancer Therapy
Abstract
Abstract Chemo‐sonodynamic synergistic therapy (CSDT) integrates the advantages of both chemodynamic therapy (CDT) and sonodynamic therapy (SDT), including specificity, non‐invasiveness, high penetration, and controllability, and it is especially suitable for deep‐seated tumors. However, there is still a lack of effective CSDT agents with long‐term stability, excellent water solubility, biocompatibility, and highly efficient catalytic activities. To address these challenges, we report a rare sonosensitive polyoxometalate (POM), H 11 [Er 2 Sb 2 W 7 O 23 (OH)(DMF) 2 (SbW 9 O 33 ) 2 ]·17H 2 O (ErSbW), featuring an atomically precise capsule‐like structure with good solubility, molecular stability, and biosafety under physiological conditions. In vitro studies reveal ErSbW's remarkable CDT efficiency in catalyzing the generation of reactive oxygen species (ROS). More importantly, the efficiency can be further distinctly augmented by three times with the presence of ultrasound irradiation, suggesting a pronounced synergistic enhancement effect in ErSbW. Most notably, ErSbW‐mediated CSDT achieved complete eradication of deep‐seated tumors in a melanoma model at the dose of 35 µg kg −1 . This work not only provides a unique POM‐based molecular agent for CSDT but also demonstrates the great potential of POM materials in synergistic cancer therapies.
Article Details
Authors (13)
Man‐Yi Du
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Hui‐Ping Xiao
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Ruo‐fei Xu
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Xian‐bin Sun
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Xin‐Yi Wang
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Dong‐Miao Li
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Sheng‐Nan Yue
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Zi‐Zhong Zhang
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated‐Materials Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University Fuzhou Fujian 350108 P.R. China
Xing Huang
Yu Gao
Xiu‐Ling Shang
Department of Critical Care Medicine, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fujian Provincial Center for Critical Care Medicine Fujian Provincial Key Laboratory of Critical Care Medicine Fuzhou P.R. China
Xin‐Xiong Li
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials College of Chemistry Fuzhou University Fuzhou Fujian China
Shou‐Tian Zheng
Fujian Provincial Key Laboratory of Advanced Inorganic Oxygenated Materials College of Chemistry Fuzhou University Fuzhou Fujian China