A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration
Abstract
Abstract The clinical course and treatment of neurodegenerative disease are complicated by immune-system interference and chronic inflammatory processes, which remain incompletely understood. Mapping immune signatures in larger human cohorts through single-cell gene expression profiling supports our understanding of observed peripheral changes in neurodegeneration. Here, we employ single-cell gene expression profiling of over 909k peripheral blood mononuclear cells (PBMCs) from 121 healthy individuals, 48 patients with mild cognitive impairment (MCI), 46 with Parkinson’s disease (PD), 27 with Alzheimer’s disease (AD), and 15 with both PD and MCI. The dataset is interactively accessible through a freely available website (https://www.ccb.uni-saarland.de/adrcsc). In this work, we identify disease-associated changes in blood cell type composition and the gene expression in a sex-specific manner, offering insights into peripheral and solid tissue signatures in AD and PD.
Article Details
Authors (28)
Friederike Grandke
Tobias Fehlmann
Fabian Kern
David M. Gate
Tobias William Wolff
Olivia Leventhal
Divya Channappa
Pascal Hirsch
Edward N. Wilson
Eckart Meese
Chuanyu Liu
Quan Shi
State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering and Environment, China University of Petroleum
Matthias Flotho
Yongping Li
Cynthia Chen
Yeya Yu
Jiangshan Xu
Michael Junkin
Zhifeng Wang
Tao Wu
Longqi Liu
Yong Hou
Katrin I. Andreasson
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Jenny S. Gansen
Elvira Mass
Kathleen Poston
Tony Wyss-Coray
Andreas Keller