A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci

Jumpei Taguchi; Mio Kikuchi; Hyojung Jeon; Ryo Shimizu; Hideto Mori; Masahito Ikawa; Yasuhiro Yamada; Kei Sato; Terumasa Ikeda; Satoshi Yamazaki; Manabu Ozawa

doi:10.1038/s41467-025-67900-4

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci

J Jumpei Taguchi (Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo) M Mio Kikuchi H Hyojung Jeon R Ryo Shimizu H Hideto Mori M Masahito Ikawa (Department of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka) Y Yasuhiro Yamada K Kei Sato T Terumasa Ikeda S Satoshi Yamazaki (Laboratory for Stem Cell Therapy, Faculty of Medicine, Tsukuba University) M Manabu Ozawa

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 14, 2026

DOI 10.1038/s41467-025-67900-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (11)

J

Jumpei Taguchi

Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo

M

Mio Kikuchi

H

Hyojung Jeon

R

Ryo Shimizu

H

Hideto Mori

M

Masahito Ikawa

Department of Experimental Genome Research, Research Institute for Microbial Diseases, The University of Osaka

Y

Yasuhiro Yamada

K

Kei Sato

T

Terumasa Ikeda

S

Satoshi Yamazaki

Laboratory for Stem Cell Therapy, Faculty of Medicine, Tsukuba University

M

Manabu Ozawa

A scalable two-step genome editing strategy for generating full-length gene-humanized mice at diverse genomic loci

Article Details

Journal Info

Authors (11)

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