A Safe Approach to <i>meta</i> ‐Fluorinated Pyridines
Abstract
ABSTRACT Since 1947, the Balz–Schiemann reaction has remained the most popular method for the synthesis of meta ‐fluoropyridines. The method involves dangerous pyridyl diazonium salts and has led to numerous documented explosions. A safe alternative to meta ‐fluoropyridines has now been developed on the basis of a 1,3‐disconnection strategy.
Article Details
Authors (6)
Oleksandra Rushchak
Enamine Ltd Kyiv Ukraine
Vadym Sham
Enamine Ltd., Winston Churchill st. 78, 02094 Kyiv, Ukraine
Bohdan Dansberg
Faculty of Chemistry Taras Shevchenko National University of Kyiv Kyiv Ukraine
Andrii Kysil
Enamine Ltd Kyiv Ukraine
Tetyana Yegorova
Faculty of Chemistry Taras Shevchenko National University of Kyiv Kyiv Ukraine
Pavel K. Mykhailiuk
Enamine Ltd, Winston Churchill St. 78, 02094 Kyiv, Ukraine