A REVIEW ON HPLC APPROACHES FOR SIMULTANEOUSLY DETERMINING ANTIHYPERTENSIVE DRUG COMBINATIONS

Abstract

Recent demand for high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties and a reduction in analysis time is a major milestone for novel methodologies, especially when analytical procedures are applied to clinical purposes. Multi-drug therapy are used to treat multiple diseases to prevent high doses of a single medicine that could produce negative effects. In recent years, fast approaches for analysing mixed compounds have been in high demand. New procedures and devices were created to meet these needs. Complex matrices can slow sample preparation and processing. Quantitative drug association profiles face issues with components, matrices, compounds, and physical-chemical complexity. We discuss HPLC methods for the determination of different combination of Benidipine hydrochloride, Metoprolol succinate, Azelnidipine, Bisoprolol Fumarate, and Cilnidipine. This study covers recently optimised procedures such as chromatographic separation, as well as methodologies that have improved accuracy, sensitivity, and selectivity in quantitative drug association analyses.