A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery

F Fabrizio Monaco (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) C Chong Lei (Department of Anesthesiology and Perioperative Medicine, Anesthesia Clinical Research Center, Xijing Hospital, Xi’an, China) M Matteo Aldo Bonizzoni (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) S Sergey Efremov (Saint-Petersburg State University Hospital, St. Petersburg, Russia) F Federica Morselli (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) F Fabio Guarracino (Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy) G Giuseppe Giardina (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) C Cristina Arangino (Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan) D Domenico Pontillo (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) M Michelangelo Vitiello (Cardiovascular Anesthesia and Intensive Care, San Carlo Hospital, Potenza, Italy) A Alessandro Belletti (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) V Valentina Ajello (Department of Cardiac Anesthesia, Tor Vergata University Hospital, Rome) M Margherita Licheri (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) C Caetano Nigro Neto (Dante Pazzanese Institute of Cardiology, São Paulo) G Gaia Barucco (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) N Nazar A. Bukamal (Mohammed Bin Khalifa Specialist Cardiac Center, Awali, Bahrain) C Carolina Faustini (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) L Lorenzo Filippo Mantovani (Department of Anesthesia and Intensive Care, Maria Cecilia Hospital, GVM International, Cotignola, Italy) A Alessandro Oriani (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) C Cristina Santonocito (Department of Anesthesia and Intensive Care Medicine III, Centro di Alte Specialità e Trapianti, Azienda Ospedaliero Universitaria Policlinico G. Rodolico–San Marco, Catania, Italy) M Marta Mucchetti (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) F Francesco Federici (Unità Operativa Complessa Anestesia e Rianimazione, Azienda Ospedaliero–Universitaria Sant’Andrea, Rome) C Chiara Gerli (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) S Sabrina Porta (S.C. Anestesia e Rianimazione Cardiovascolare, Azienda Ospedaliera Ordine Mauriziano Umberto I di Torino, Turin, Italy) A Anna Mara Scandroglio (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) H Hui Zhang (The Fourth Hospital of Hebei Medical University Shijiazhuang China) M Marina Pieri (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) R Roman Osinsky (Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia) S Stefano Lazzari (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) E Elizaveta Leonova (Saint-Petersburg State University Hospital, St. Petersburg, Russia) M Maria Grazia Calabrò (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) D Daniele Amitrano (Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy) S Stefano Turi (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) P Paolo Prati S Stefano Fresilli (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) F Filippo D’Amico (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) J Jacopo D’Andria Ursoleo (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) R Rosa Labanca (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) M Marilena Marmiere (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) A Alessandro Pruna (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) T Tommaso Scquizzato (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) K Kaan Kırali (Department of Cardiovascular Surgery, Kosuyolu High Specialization Education and Research Hospital, Istanbul, Turkey) G Giacomo Monti (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan) M Maria José Carvalho Carmona (Instituto do Coração, InCor, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo) K Kenichi Tanaka (Department of Anesthesiology, University of Oklahoma Health, Oklahoma City) V Valery Likhvantsev (Federal Clinical and Research Center of Intensive Care and Rehabilitation, Moscow) L Lian Kah Ti (Department of Anaesthesia, National University Hospital, Singapore) T Tiziana Bove (Department of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale Santa Maria della Misericordia, Udine, Italy) G Gianluca Paternoster (Department of Health Science, Anesthesia and Intensive Care, School of Medicine, University of Basilicata San Carlo Hospital, Potenza, Italy) K Karen Singh (University of Virginia Health, Charlottesville) M Mustafa Emre Gürcü (Department of Anesthesiology, Kosuyolu High Specialization Education and Research Hospital, Istanbul, Turkey) V Vladimir Lomivorotov (Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia) G Giovanni Landoni R Rinaldo Bellomo (Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia) A Alberto Zangrillo (Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan)

Article Details

Volume / Issue Vol. 393, Issue 5
Published July 31, 2025
Pages 450-460
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (55)

F

Fabrizio Monaco

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

C

Chong Lei

Department of Anesthesiology and Perioperative Medicine, Anesthesia Clinical Research Center, Xijing Hospital, Xi’an, China

M

Matteo Aldo Bonizzoni

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

S

Sergey Efremov

Saint-Petersburg State University Hospital, St. Petersburg, Russia

F

Federica Morselli

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

F

Fabio Guarracino

Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

G

Giuseppe Giardina

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

C

Cristina Arangino

Department of Cardiothoracic Anesthesia and Intensive Care, IRCCS Centro Cardiologico Monzino, Milan

D

Domenico Pontillo

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

M

Michelangelo Vitiello

Cardiovascular Anesthesia and Intensive Care, San Carlo Hospital, Potenza, Italy

A

Alessandro Belletti

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

V

Valentina Ajello

Department of Cardiac Anesthesia, Tor Vergata University Hospital, Rome

M

Margherita Licheri

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

C

Caetano Nigro Neto

Dante Pazzanese Institute of Cardiology, São Paulo

G

Gaia Barucco

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

N

Nazar A. Bukamal

Mohammed Bin Khalifa Specialist Cardiac Center, Awali, Bahrain

C

Carolina Faustini

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

L

Lorenzo Filippo Mantovani

Department of Anesthesia and Intensive Care, Maria Cecilia Hospital, GVM International, Cotignola, Italy

A

Alessandro Oriani

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

C

Cristina Santonocito

Department of Anesthesia and Intensive Care Medicine III, Centro di Alte Specialità e Trapianti, Azienda Ospedaliero Universitaria Policlinico G. Rodolico–San Marco, Catania, Italy

M

Marta Mucchetti

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

F

Francesco Federici

Unità Operativa Complessa Anestesia e Rianimazione, Azienda Ospedaliero–Universitaria Sant’Andrea, Rome

C

Chiara Gerli

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

S

Sabrina Porta

S.C. Anestesia e Rianimazione Cardiovascolare, Azienda Ospedaliera Ordine Mauriziano Umberto I di Torino, Turin, Italy

A

Anna Mara Scandroglio

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

H

Hui Zhang

The Fourth Hospital of Hebei Medical University Shijiazhuang China

M

Marina Pieri

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

R

Roman Osinsky

Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia

S

Stefano Lazzari

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

E

Elizaveta Leonova

Saint-Petersburg State University Hospital, St. Petersburg, Russia

M

Maria Grazia Calabrò

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

D

Daniele Amitrano

Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

S

Stefano Turi

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

P

Paolo Prati

S

Stefano Fresilli

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

F

Filippo D’Amico

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

J

Jacopo D’Andria Ursoleo

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

R

Rosa Labanca

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

M

Marilena Marmiere

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

A

Alessandro Pruna

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

T

Tommaso Scquizzato

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

K

Kaan Kırali

Department of Cardiovascular Surgery, Kosuyolu High Specialization Education and Research Hospital, Istanbul, Turkey

G

Giacomo Monti

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan

M

Maria José Carvalho Carmona

Instituto do Coração, InCor, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo

K

Kenichi Tanaka

Department of Anesthesiology, University of Oklahoma Health, Oklahoma City

V

Valery Likhvantsev

Federal Clinical and Research Center of Intensive Care and Rehabilitation, Moscow

L

Lian Kah Ti

Department of Anaesthesia, National University Hospital, Singapore

T

Tiziana Bove

Department of Emergency, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale Santa Maria della Misericordia, Udine, Italy

G

Gianluca Paternoster

Department of Health Science, Anesthesia and Intensive Care, School of Medicine, University of Basilicata San Carlo Hospital, Potenza, Italy

K

Karen Singh

University of Virginia Health, Charlottesville

M

Mustafa Emre Gürcü

Department of Anesthesiology, Kosuyolu High Specialization Education and Research Hospital, Istanbul, Turkey

V

Vladimir Lomivorotov

Department of Anesthesiology and Intensive Care, E. Meshalkin National Medical Research Center, Novosibirsk, Russia

G

Giovanni Landoni

R

Rinaldo Bellomo

Department of Critical Care, University of Melbourne, Melbourne, VIC, Australia

A

Alberto Zangrillo

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan