A hybrid CNN-Transformer network integrating multiscale spatially detailed features for medical image segmentation

B Bo Li W Wei Zhou H Haijun Li (College of Chemistry, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, P.R. China)

Abstract

The rapid advancement of deep learning has established Convolutional Neural Networks (CNNs) as mainstream for medical image segmentation, yet their limited receptive field hinders long-range dependency capture. While Transformers excel at modeling global features via self-attention, their high computational complexity burdens high-resolution image processing. To leverage the complementary strengths of both architectures and integrate local and global features under a lightweight framework for enhanced accuracy and efficiency, this work proposes a novel encoder based on parallel CNN and Swin Transformer. Its effective integration is the Semantics and Detail Infusion (SDI) module, which fuses multi-scale features and employs attention to prioritize critical details, enriching features for decoder resolution recovery. Evaluations were conducted on two publicly available datasets, namely the Synapse Multi-Organ Segmentation dataset and the Aortic Vessel Tree dataset. The proposed model achieved Dice coefficients of 84.19% and 87.91%, respectively, and corresponding Hausdorff Distances of 12.64 mm and 7.06 mm. These results represent significant improvements over the UNet benchmark, with Dice score gains of 7.34% and 5.02%, respectively. The results further underscore the model’s robustness, efficiency, and clinical relevance in accurately delineating complex anatomical structures, particularly in abdominal segmentation tasks. By effectively fusing CNN and Transformer advantages, our approach meets high-performance standards for medical image segmentation while offering practical benefits for real-world clinical deployment in resource-constrained environments. The code is publicly available on https://github.com/Palpitate-v/HybridNet .

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 4
Published April 29, 2026
Pages e0345549
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (3)

B

Bo Li

W

Wei Zhou

H

Haijun Li

College of Chemistry, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, P.R. China