A Hooker Oxygenase Archetype in Polyketide Biosynthesis Challenging the Baeyer–Villiger Monooxygenase Paradigm

H Heiner G. Weddeling (Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland) S Sven T. Sowa (Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland) E Elena Bialas (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences) S Sven Reese (Fakultät für Chemie und Biochemie, Organische Chemie II, Universitätsstraße 150, Bochum 44801, Germany) C Christian Merten (Fakultät für Chemie und Biochemie, Organische Chemie II, Universitätsstraße 150, Bochum 44801, Germany) M Markus Lill (Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland) A Andreas Bechthold (Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences) R Robin Teufel (Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland)

Article Details

Volume / Issue Vol. 148, Issue 5
Published February 11, 2026
Pages 5722-5733
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

H

Heiner G. Weddeling

Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland

S

Sven T. Sowa

Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland

E

Elena Bialas

Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences

S

Sven Reese

Fakultät für Chemie und Biochemie, Organische Chemie II, Universitätsstraße 150, Bochum 44801, Germany

C

Christian Merten

Fakultät für Chemie und Biochemie, Organische Chemie II, Universitätsstraße 150, Bochum 44801, Germany

M

Markus Lill

Computational Pharmacy, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland

A

Andreas Bechthold

Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences

R

Robin Teufel

Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, Basel 4056, Switzerland