A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases
Abstract
Abstract Cardiovascular diseases (CVD) remain a major global health challenge. Early markers of disease initiation and progression are urgently needed. We, and others, have previously shown changes in the gut microbiome in association with metabolic and CVD. Here, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. Markers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy European population. Observational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident CVD in an external Canadian population. Altogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of CVD.
Article Details
Authors (136)
Kanta Chechi
Rima Chakaroun
Antonis Myridakis
Sofia K. Forslund-Startceva
Sébastien Fromentin
Trine Nielsen
Judith Aron-Wisneswky
Eugeni Belda
Edi Prifti
Pierre Bel Lassen
Gwen Falony
Sara Vieira-Silva
Julien Chilloux
Kazuhiro Sonomura
Lesley Hoyles
Laura Martinez-Gili
Francesco Pallotti
Petros Andrikopoulos
Francesc Puig-Castellví
Romina Pacheco Tapia
Inés Castro-Dionicio
Hugo Roume
Nicolas Pons
Emmanuelle Le Chatelier
Benoît Quinquis
Nathalie Galleron
Magali Berland
Michael T. Olanipekun
Manyi Jia
Angelos Manolias
Bridget Holmes
Solia Adriouch
Matthias Blüher
Luis Pedro Coelho
Kévin Da Silva
Pilar Galan
Boyang Ji
Ana Luísa Neves
Christine Rouault
Joe-Elie Salem
Valentina Tremaroli
Tue H. Hansen
Nadja B. Søndertoft
Christian Lewinter
Helle K. Pedersen
Rohia Alili
Chloe Amouyal
Karen Assmann
Ehm Astrid Andersson Galijatovic
Fabrizio Andreelli
Olivier Barthelemy
Jean-Philippe Bastard
Jean-Paul Batisse
Randa Bittar
Hervé Blottière
Frederic Bosquet
Rachid Boubrit
Olivier Bourron
Mickael Camus
Dominique Cassuto
Cécile Ciangura
Jean-Philippe Collet
Maria-Carlota Dao
Morad Djebbar
Angélique Doré
Line Engelbrechtsen
Soraya Fellahi
Leopold Fezeu
Philippe Giral
Agnes Hartemann
Bolette Hartmann
Gerard Helft
Jens Juul Holst
Marlene Hornbak
Andrea Rodriguez-Martinez
Jean-Sébastien Hulot
Richard Isnard
Sophie Jaqueminet
Niklas Rye Jørgensen
Hanna Julienne
Johanne Justesen
Judith Kammer
Nikolaj Karup
Mathieu Kerneis
AP-HP, Hôpital Pitié–Salpêtrière, Paris
Jean Khemis
Michael Kuhn
Véronique Lejard
Florence Levenez
Lea Lucas-Martini
Robin Massey
Nicolas Maziers
Jonathan Medina-Stamminger
Gilles Montalescot
Sorbonne Université, Paris
Sandrine Moutel
Laetitia Pasero Le Pavin
Christine Poitou-Bernert
Francoise Pousset
Laurence Pouzoulet
Lucas Moitinho-Silva
Johanne Silvain
Mathilde Svendstrup
Timothy Swartz
Thierry Vanduyvenboden
Camille Vatier
Stefanie Walther
Eric Verger
Aurélie Lampure
Peter D. Mark
Jens P. Goetze
Lars Køber
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen
Henrik Vestergaard
Torben Hansen
Jean-Daniel Zucker
Taka-Aki Sato
Serge Hercberg
Fredrik Bäckhed
Ivica Letunic
Jean-Michel Oppert
Jens Nielsen
Jeroen Raes
Ioanna Tzoulaki
Abbas Dehghan
Verena Zuber
Emmanuelle Bouzigon
Mark Lathrop
Parminder Raina
Philippe Froguel
Fumihiko Matsuda
Florence Demenais
Dominique Gauguier
Michael Stumvoll
Peer Bork
Oluf Pedersen
S. Dusko Ehrlich
Karine Clément
Marc-Emmanuel Dumas