A generalized epilepsy network derived from brain abnormalities and deep brain stimulation
Abstract
Abstract Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging. The topography of the IGE network aligns with brain networks involved in motor control and loss of consciousness consistent with generalized seizure semiology. To investigate therapeutic relevance, we analyze data from 21 patients with IGE treated with deep brain stimulation (DBS) for generalized seizures. Seizure frequency reduced a median 90% after DBS and stimulation sites intersect an IGE network peak in the centromedian nucleus of the thalamus. Together, this study helps unify prior findings in IGE and identify a brain network target that can be tested in clinical trials of brain stimulation to control generalized seizures.
Article Details
Authors (44)
Gong-Jun Ji
Michael D. Fox
Mae Morton-Dutton
Yingru Wang
Jinmei Sun
Panpan Hu
Xingui Chen
Yubao Jiang
Chunyan Zhu
Frontiers Science Center for New Organic Matter, Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), State Key Laboratory of Advanced Chemical Power Sources, College of Chemistry
Yanghua Tian
Zhiqiang Zhang
Haya Akkad
Janne Nordberg
Juho Joutsa
Cristina V. Torres Diaz
Sergiu Groppa
Gabriel Gonzalez-Escamilla
Maria de Toledo
Linda J. Dalic
John S. Archer
Richard Selway
Ioannis Stavropoulos
Antonio Valentin
Jimmy Yang
Faical Isbaine
Robert E. Gross
Sihyeong Park
Nicholas M. Gregg
Department of Neurology, Mayo Clinic
Arthur Cukiert
Erik H. Middlebrooks
Nico U. F. Dosenbach
Joseph Turner
Aaron E. L. Warren
Melissa M. J. Chua
Alexander L. Cohen
Sara Larivière
Clemens Neudorfer
Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women’s Hospital, Harvard Medical School
Andreas Horn
Rani A. Sarkis
Ellen J. Bubrick
Robert S. Fisher
John D. Rolston
Kai Wang
Frederic L. W. V. J. Schaper