A fully integrated smart ring for daily biochemical monitoring
Abstract
Abstract Biochemical analysis complements biophysical measurements by capturing the underlying molecular and metabolic changes that drive physiological health. Here, we introduce a compact, fully integrated smart ring capable of simultaneously monitoring multiple chemical biomarkers in real-time — marking a true biochemical counterpart to existing smart rings. Our ring can continuously measure glucose, ketone, ascorbic acid, uric acid, lactate, and alcohol from passive osmotically extracted sweat, is powered by custom-built high-capacity flexible Zn-AgO batteries, and comprises ultra-compact, energy-efficient electronics for data processing and wireless transmission. It can support ~12 hours of continuous monitoring and preserves personalized calibration stability for ~2 months. The simultaneous biomarker monitoring was validated under diverse daily settings. Reliable, continuous monitoring of glucose and ketone levels showed strong agreement with commercial blood meters and continuous glucose monitors in both healthy and type 1 diabetic individuals, confirming the ring’s accuracy even for at-risk population. Overall, our ring extends beyond commercial smart rings focusing on only biophysical signals, by enabling continuous assessment of biochemical changes and advancing the development of next generation personalized and miniaturized healthcare technologies.
Article Details
Authors (21)
Tamoghna Saha
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Shichao Ding
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Siyu Qin
Hannah Fishman
Rosie Pham
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Te Gu
Muyang Lin
Yushan Xian
Barak Sabbagh
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Abdulhameed Abdal
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0448, United States
Gaoyuan Ji
Department of Electrical and Computer Engineering, University of California, San Diego
Kittiya Sakdaphetsiri
Yi Fung Winsten Lam
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering
Muhammad Inam Khan
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Hao Luan
Zongnan Wang
Department of Mechanical Engineering, University of California, San Diego
Selene Tang
Omeed Djassemi
Samar Singh Sandhu
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego
Sheng Xu
Joseph Wang
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering