A foundation model for atomistic materials chemistry

I Ilyes Batatia P Philipp Benner (Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,) Y Yuan Chiang (Department of Materials Science and Engineering, University of California 3 , Berkeley, California 94720,) A Alin M. Elena (Scientific Computing Department, Science and Technology Facilities Council, Daresbury Laboratory 5 , Keckwick Lane, Daresbury WA4 4AD,) D Dávid P. Kovács (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) J Janosh Riebesell (Materials Sciences Division, Lawrence Berkeley National Laboratory 4 , Berkeley, California 94720,) X Xavier R. Advincula (Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.) M Mark Asta (Materials Sciences Division) M Matthew Avaylon (Scientific Data Division) W William J. Baldwin (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) F Fabian Berger (Institut für Chemie, Humboldt-Universität zu Berlin, Unter den Linden 6, Berlin 10117, Germany) N Noam Bernstein (U.S. Naval Research Laboratory 9 , Washington, District of Columbia 20375,) A Arghya Bhowmik (Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,) F Filippo Bigi S Samuel M. Blau (Energy Technologies Area, Lawrence Berkeley National Laboratory 12 , Berkeley, California 94720,) V Vlad Cărare (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) M Michele Ceriotti (Laboratory of Computational Science and Modeling, Institute of Materials, École Polytechnique Fédérale de Lausanne 1 , 1015 Lausanne,) S Sanggyu Chong (Laboratory of Computational Science and Modeling, Institute of Materials, École Polytechnique Fédérale de Lausanne 1 , 1015 Lausanne,) J James P. Darby (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) S Sandip De (BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany) F Flaviano Della Pia (Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,) V Volker L. Deringer (Inorganic Chemistry Laboratory, Department of Chemistry) R Rokas Elijošius (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) Z Zakariya El-Machachi (Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,) E Edvin Fako (Laboratory of Artificial Chemical Intelligence) F Fabio Falcioni (InstaDeep 15 , London W2 1AY,) A Andrea C. Ferrari (Cambridge Graphene Centre, University of Cambridge 16 , Cambridge CB3 0FA,) J John L. A. Gardner (Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,) M Mikołaj J. Gawkowski (Department of Physics and Astronomy, University College London 17 , London WC1E 6BT,) A Annalena Genreith-Schriever (Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,) J Janine George (Materials Chemistry Department, Federal Institute for Materials Research and Testing (BAM), Unter den Eichen 87, Berlin 12205, Germany) R Rhys E. A. Goodall (Chemix, Inc. 19 , Sunnyvale, California 94085,) J Jonas Grandel (Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,) C Clare P. Grey (Yusuf Hamied Department of Chemistry) P Petr Grigorev (Aix-Marseille Université, CNRS, CINaM UMR 7325, Campus de Luminy 20 , 13288 Marseille,) S Shuang Han (BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany) W Will Handley (Cavendish Laboratory, University of Cambridge 6 , J. J. Thomson Ave., Cambridge,) H Hendrik H. Heenen (Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,) K Kersti Hermansson (Department of Chemistry-Ångström) C Cheuk Hin Ho (Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,) S Stephan Hofmann C Christian Holm (Institute for Computational Physics, University of Stuttgart , D-70569 Stuttgart,) J Jad Jaafar (Department of Engineering) K Konstantin S. Jakob (Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,) H Hyunwook Jung (Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,) V Venkat Kapil A Aaron D. Kaplan (Materials Sciences Division, Lawrence Berkeley National Laboratory 4 , Berkeley, California 94720,) N Nima Karimitari (Department of Chemistry and Biochemistry, University of South Carolina 27 , Columbia, South Carolina 29208,) J James R. Kermode (Warwick Centre for Predictive Modelling, School of Engineering, University of Warwick 28 , Coventry CV4 7AL,) P Panagiotis Kourtis (School of Natural and Environmental Science, Newcastle University 29 , Newcastle upon Tyne NE1 7RU,) N Namu Kroupa (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) J Jolla Kullgren (Department of Chemistry-Ångström, Structural Chemistry Division, Uppsala University 2 , Lägerhyddsvägen 1, Uppsala 751 20,) M Matthew C. Kuner (Department of Materials Science and Engineering, University of California 3 , Berkeley, California 94720,) D Domantas Kuryla (Yusuf Hamied Department of Chemistry, University of Cambridge 1 , Lensfield Road, Cambridge,) G Guoda Liepuoniute (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) C Chen Lin (School of Pharmaceutical Sciences) J Johannes T. Margraf (University of Bayreuth, Bavarian Center for Battery Technology (BayBatt), Bayreuth, Germany and Fritz-Haber-Institut der Max-Planck-Gesellschaft 2 , Berlin,) I Ioan-Bogdan Magdău (School of Natural and Environmental Sciences) A Angelos Michaelides J J. Harry Moore (Engineering Laboratory) A Aakash A. Naik (Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,) S Samuel P. Niblett (Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,) S Sam Walton Norwood (Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,) N Niamh O’Neill (Cavendish Laboratory, University of Cambridge 6 , J. J. Thomson Ave., Cambridge,) C Christoph Ortner (Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,) K Kristin A. Persson K Karsten Reuter (Theory Department, Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany) A Andrew S. Rosen (Department of Chemical and Biological Engineering) L Louise A. M. Rosset (Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,) L Lars L. Schaaf (Cavendish Laboratory, Department of Physics, University of Cambridge 2 , Cambridge CB3 0HE,) C Christoph Schran B Benjamin X. Shi (Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,) E Eric Sivonxay (Energy Technologies Area, Lawrence Berkeley National Laboratory 12 , Berkeley, California 94720,) T Tamás K. Stenczel (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) C Christopher Sutton (Department of Chemistry and Biochemistry, University of South Carolina 27 , Columbia, South Carolina 29208,) V Viktor Svahn (Department of Chemistry–Ångström, Uppsala University 24 , Box 538, S-751 21 Uppsala,) T Thomas D. Swinburne (Aix-Marseille Université, CNRS, CINaM UMR 7325, Campus de Luminy 20 , 13288 Marseille,) J Jules Tilly (InstaDeep 15 , London W2 1AY,) C Cas van der Oord (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) S Santiago Vargas (Department of Chemistry and Biochemistry, University of California – Los Angeles 35 , 607 Charles E. Young Drive East, Los Angeles, California 90095,) E Eszter Varga-Umbrich (Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,) T Tejs Vegge (Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,) M Martin Vondrák (Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,) Y Yangshuai Wang (Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,) W William C. Witt (Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, U.K.) T Thomas Wolf (Linac Coherent Light Source, SLAC National Accelerator Laboratory 5 , 2575 Sand Hill Road, Menlo Park, California 94025,) F Fabian Zills (Institute for Computational Physics, University of Stuttgart 26 , 70569 Stuttgart,) G Gábor Csányi

Abstract

Atomistic simulations of matter, especially those that leverage first-principles (ab initio) electronic structure theory, provide a microscopic view of the world, underpinning much of our understanding of chemistry and materials science. Over the last decade or so, machine-learned force fields have transformed atomistic modeling by enabling simulations of ab initio quality over unprecedented time and length scales. However, early machine-learning (ML) force fields have largely been limited by (i) the substantial computational and human effort required to develop and validate potentials for each particular system of interest and (ii) a general lack of transferability from one chemical system to the next. Here, we show that it is possible to create a general-purpose atomistic ML model, trained on a public dataset of moderate size, that is capable of running stable molecular dynamics for a wide range of molecules and materials. We demonstrate the power of the MACE-MP-0 model—and its qualitative and at times quantitative accuracy—on a diverse set of problems in the physical sciences, including properties of solids, liquids, gases, chemical reactions, interfaces, and even the dynamics of a small protein. The model can be applied out of the box as a starting or “foundation” model for any atomistic system of interest and, when desired, can be fine-tuned on just a handful of application-specific data points to reach ab initio accuracy. Establishing that a stable force-field model can cover almost all materials changes atomistic modeling in a fundamental way: experienced users obtain reliable results much faster, and beginners face a lower barrier to entry. Foundation models thus represent a step toward democratizing the revolution in atomic-scale modeling that has been brought about by ML force fields.

Article Details

Volume / Issue Vol. 163, Issue 18
Published November 14, 2025
ISSN 0021-9606
Publisher American Institute of Physics

Journal Info

The Journal of Chemical Physics

American Institute of Physics

ISSN: 0021-9606 Physical Sciences

Authors (88)

I

Ilyes Batatia

P

Philipp Benner

Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,

Y

Yuan Chiang

Department of Materials Science and Engineering, University of California 3 , Berkeley, California 94720,

A

Alin M. Elena

Scientific Computing Department, Science and Technology Facilities Council, Daresbury Laboratory 5 , Keckwick Lane, Daresbury WA4 4AD,

D

Dávid P. Kovács

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

J

Janosh Riebesell

Materials Sciences Division, Lawrence Berkeley National Laboratory 4 , Berkeley, California 94720,

X

Xavier R. Advincula

Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

M

Mark Asta

Materials Sciences Division

M

Matthew Avaylon

Scientific Data Division

W

William J. Baldwin

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

F

Fabian Berger

Institut für Chemie, Humboldt-Universität zu Berlin, Unter den Linden 6, Berlin 10117, Germany

N

Noam Bernstein

U.S. Naval Research Laboratory 9 , Washington, District of Columbia 20375,

A

Arghya Bhowmik

Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,

F

Filippo Bigi

S

Samuel M. Blau

Energy Technologies Area, Lawrence Berkeley National Laboratory 12 , Berkeley, California 94720,

V

Vlad Cărare

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

M

Michele Ceriotti

Laboratory of Computational Science and Modeling, Institute of Materials, École Polytechnique Fédérale de Lausanne 1 , 1015 Lausanne,

S

Sanggyu Chong

Laboratory of Computational Science and Modeling, Institute of Materials, École Polytechnique Fédérale de Lausanne 1 , 1015 Lausanne,

J

James P. Darby

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

S

Sandip De

BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany

F

Flaviano Della Pia

Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,

V

Volker L. Deringer

Inorganic Chemistry Laboratory, Department of Chemistry

R

Rokas Elijošius

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

Z

Zakariya El-Machachi

Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,

E

Edvin Fako

Laboratory of Artificial Chemical Intelligence

F

Fabio Falcioni

InstaDeep 15 , London W2 1AY,

A

Andrea C. Ferrari

Cambridge Graphene Centre, University of Cambridge 16 , Cambridge CB3 0FA,

J

John L. A. Gardner

Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,

M

Mikołaj J. Gawkowski

Department of Physics and Astronomy, University College London 17 , London WC1E 6BT,

A

Annalena Genreith-Schriever

Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,

J

Janine George

Materials Chemistry Department, Federal Institute for Materials Research and Testing (BAM), Unter den Eichen 87, Berlin 12205, Germany

R

Rhys E. A. Goodall

Chemix, Inc. 19 , Sunnyvale, California 94085,

J

Jonas Grandel

Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,

C

Clare P. Grey

Yusuf Hamied Department of Chemistry

P

Petr Grigorev

Aix-Marseille Université, CNRS, CINaM UMR 7325, Campus de Luminy 20 , 13288 Marseille,

S

Shuang Han

BASF SE, Carl-Bosch-Straße 38, 67056 Ludwigshafen, Germany

W

Will Handley

Cavendish Laboratory, University of Cambridge 6 , J. J. Thomson Ave., Cambridge,

H

Hendrik H. Heenen

Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,

K

Kersti Hermansson

Department of Chemistry-Ångström

C

Cheuk Hin Ho

Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,

S

Stephan Hofmann

C

Christian Holm

Institute for Computational Physics, University of Stuttgart , D-70569 Stuttgart,

J

Jad Jaafar

Department of Engineering

K

Konstantin S. Jakob

Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,

H

Hyunwook Jung

Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,

V

Venkat Kapil

A

Aaron D. Kaplan

Materials Sciences Division, Lawrence Berkeley National Laboratory 4 , Berkeley, California 94720,

N

Nima Karimitari

Department of Chemistry and Biochemistry, University of South Carolina 27 , Columbia, South Carolina 29208,

J

James R. Kermode

Warwick Centre for Predictive Modelling, School of Engineering, University of Warwick 28 , Coventry CV4 7AL,

P

Panagiotis Kourtis

School of Natural and Environmental Science, Newcastle University 29 , Newcastle upon Tyne NE1 7RU,

N

Namu Kroupa

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

J

Jolla Kullgren

Department of Chemistry-Ångström, Structural Chemistry Division, Uppsala University 2 , Lägerhyddsvägen 1, Uppsala 751 20,

M

Matthew C. Kuner

Department of Materials Science and Engineering, University of California 3 , Berkeley, California 94720,

D

Domantas Kuryla

Yusuf Hamied Department of Chemistry, University of Cambridge 1 , Lensfield Road, Cambridge,

G

Guoda Liepuoniute

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

C

Chen Lin

School of Pharmaceutical Sciences

J

Johannes T. Margraf

University of Bayreuth, Bavarian Center for Battery Technology (BayBatt), Bayreuth, Germany and Fritz-Haber-Institut der Max-Planck-Gesellschaft 2 , Berlin,

I

Ioan-Bogdan Magdău

School of Natural and Environmental Sciences

A

Angelos Michaelides

J

J. Harry Moore

Engineering Laboratory

A

Aakash A. Naik

Federal Institute of Materials Research and Testing (BAM) 2 , Berlin,

S

Samuel P. Niblett

Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,

S

Sam Walton Norwood

Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,

N

Niamh O’Neill

Cavendish Laboratory, University of Cambridge 6 , J. J. Thomson Ave., Cambridge,

C

Christoph Ortner

Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,

K

Kristin A. Persson

K

Karsten Reuter

Theory Department, Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany

A

Andrew S. Rosen

Department of Chemical and Biological Engineering

L

Louise A. M. Rosset

Inorganic Chemistry Laboratory, Department of Chemistry, University of Oxford 14 , Oxford OX1 3QR,

L

Lars L. Schaaf

Cavendish Laboratory, Department of Physics, University of Cambridge 2 , Cambridge CB3 0HE,

C

Christoph Schran

B

Benjamin X. Shi

Yusuf Hamied Department of Chemistry, University of Cambridge 7 , Lensfield Road, Cambridge,

E

Eric Sivonxay

Energy Technologies Area, Lawrence Berkeley National Laboratory 12 , Berkeley, California 94720,

T

Tamás K. Stenczel

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

C

Christopher Sutton

Department of Chemistry and Biochemistry, University of South Carolina 27 , Columbia, South Carolina 29208,

V

Viktor Svahn

Department of Chemistry–Ångström, Uppsala University 24 , Box 538, S-751 21 Uppsala,

T

Thomas D. Swinburne

Aix-Marseille Université, CNRS, CINaM UMR 7325, Campus de Luminy 20 , 13288 Marseille,

J

Jules Tilly

InstaDeep 15 , London W2 1AY,

C

Cas van der Oord

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

S

Santiago Vargas

Department of Chemistry and Biochemistry, University of California – Los Angeles 35 , 607 Charles E. Young Drive East, Los Angeles, California 90095,

E

Eszter Varga-Umbrich

Engineering Laboratory, University of Cambridge 1 , Trumpington St. and JJ Thomson Ave., Cambridge,

T

Tejs Vegge

Department of Energy Conversion and Storage, Technical University of Denmark 10 , Anker Engelunds Vej 301, 2800 Kgs. Lyngby,

M

Martin Vondrák

Fritz-Haber-Institute of the Max-Planck-Society 23 , Berlin,

Y

Yangshuai Wang

Mathematics Department, University of British Columbia 25 , 1984 Mathematics Rd., Vancouver, British Columbia V6T 1Z2,

W

William C. Witt

Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, U.K.

T

Thomas Wolf

Linac Coherent Light Source, SLAC National Accelerator Laboratory 5 , 2575 Sand Hill Road, Menlo Park, California 94025,

F

Fabian Zills

Institute for Computational Physics, University of Stuttgart 26 , 70569 Stuttgart,

G

Gábor Csányi