A DNA Origami-Based Cobweb Facilitates Precise and Receptor-Interference Free Modification of Extracellular Vesicle Mimetic for Enhanced Delivery Efficacy

S Shijun Cai (Hangzhou Institute of Medicine) R Rui Xu (College & Hospital of Stomatology) Y Yuan Tian A Anqi Song (Hangzhou Institute of Medicine) N Nannan Diao (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) H Haowen Li (Hangzhou Institute of Medicine) L Linlin Yang (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) Y Yumeng Zhao (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) X Xuemei Xu (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) Q Qianqian Gao (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) C Chao Zhang Y Yanyan Miao (Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine) M Mengyao Zhao (Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Shanghai Wusong Laboratory of Materials Science) Q Qian Tang (Hangzhou Institute of Medicine) D Da Han (Hangzhou Institute of Medicine)

Article Details

Volume / Issue Vol. 148, Issue 15
Published April 22, 2026
Pages 16008-16018
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

S

Shijun Cai

Hangzhou Institute of Medicine

R

Rui Xu

College & Hospital of Stomatology

Y

Yuan Tian

A

Anqi Song

Hangzhou Institute of Medicine

N

Nannan Diao

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

H

Haowen Li

Hangzhou Institute of Medicine

L

Linlin Yang

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

Y

Yumeng Zhao

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

X

Xuemei Xu

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

Q

Qianqian Gao

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

C

Chao Zhang

Y

Yanyan Miao

Institute of Molecular Medicine and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine

M

Mengyao Zhao

Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Shanghai Wusong Laboratory of Materials Science

Q

Qian Tang

Hangzhou Institute of Medicine

D

Da Han

Hangzhou Institute of Medicine