A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader

Monica C. Rodrigo-Brenni; Jasper C. Komen; Ghaith M. Hamza; Natacha Bohin; Tomas Adomavicius; Angelo Andres; Stefan Blaho; Ulf Börjesson; Gavin W. Collie; Gian Marco De Donatis; Frederik Eisele; Ning Gao; Andrea Gohlke; Christoph Grebner; Frida Gustafsson; Andreas Hock; Cecilia Kankkonen; Praveen Kumar; Emilyanne Leonard; Xin Li; Ruth Macdonald; Katja Madeyski-Bengtson; Eric Miele; Philip Nevin; Jeroen Overman; Fiona Pachl; Claudio Pathe; Matthew W. D. Perry; Christopher Phillips; Andy Pike; Ian Purvis; Timothy Rasmusson; Sophie Regan; Linda Reilly; Jonathan Rose; R. Ian Storer; Jingwen Wang; Xiang Zhai; Iacovos N. Michaelides; Kevin Moreau

doi:10.1038/s41467-026-70663-1

A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader

M Monica C. Rodrigo-Brenni J Jasper C. Komen G Ghaith M. Hamza N Natacha Bohin T Tomas Adomavicius A Angelo Andres S Stefan Blaho U Ulf Börjesson G Gavin W. Collie G Gian Marco De Donatis F Frederik Eisele N Ning Gao (Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences) A Andrea Gohlke C Christoph Grebner F Frida Gustafsson A Andreas Hock C Cecilia Kankkonen P Praveen Kumar E Emilyanne Leonard X Xin Li R Ruth Macdonald K Katja Madeyski-Bengtson E Eric Miele P Philip Nevin J Jeroen Overman F Fiona Pachl C Claudio Pathe M Matthew W. D. Perry C Christopher Phillips A Andy Pike I Ian Purvis T Timothy Rasmusson S Sophie Regan L Linda Reilly J Jonathan Rose R R. Ian Storer (Hit Discovery, Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Ave, Cambridge CB2 0AA, U.K.) J Jingwen Wang X Xiang Zhai I Iacovos N. Michaelides K Kevin Moreau

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published March 25, 2026

DOI 10.1038/s41467-026-70663-1

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (40)

M

Monica C. Rodrigo-Brenni

J

Jasper C. Komen

G

Ghaith M. Hamza

N

Natacha Bohin

T

Tomas Adomavicius

A

Angelo Andres

S

Stefan Blaho

U

Ulf Börjesson

G

Gavin W. Collie

G

Gian Marco De Donatis

F

Frederik Eisele

N

Ning Gao

Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

A

Andrea Gohlke

C

Christoph Grebner

F

Frida Gustafsson

A

Andreas Hock

C

Cecilia Kankkonen

P

Praveen Kumar

E

Emilyanne Leonard

X

Xin Li

R

Ruth Macdonald

K

Katja Madeyski-Bengtson

E

Eric Miele

P

Philip Nevin

J

Jeroen Overman

F

Fiona Pachl

C

Claudio Pathe

M

Matthew W. D. Perry

C

Christopher Phillips

A

Andy Pike

I

Ian Purvis

T

Timothy Rasmusson

S

Sophie Regan

L

Linda Reilly

J

Jonathan Rose

R

R. Ian Storer

Hit Discovery, Discovery Sciences, R&D, AstraZeneca, 1 Francis Crick Ave, Cambridge CB2 0AA, U.K.

J

Jingwen Wang

X

Xiang Zhai

I

Iacovos N. Michaelides

K

Kevin Moreau

A dihydrouracil CRBN ligand mitigates IMiD associated safety liabilities in heterobifunctional targeted protein degrader

Article Details

Journal Info

Authors (40)

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