A computational model to describe multi-regional brain architecture during neurodegeneration in Alzheimer’s disease
Abstract
Abstract We previously proposed an MRI-based machine learning model to describe the mesoscopic architecture of the human brain to aid in classifying subjects as having non-AD related pathology (nADrp) or AD related pathology (ADrp), including mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The method, developed on data from patients scanned at 1.5T showed high performance, but did not generalise well to scans obtained from 3T MRI. In the current work we overcome the problem and extend the approach to patients scanned longitudinally, and at different field strengths. Retrospective T1-MRI data from 1592 subjects scanned at 3T were included to develop the machine learning models. Three additional longitudinal datasets (n = 211) at different magnetic field strengths—1.5 and 3T—were adopted to evaluate the models. Radiomic features were extracted from each brain region. A logistic regression method with least absolute shrinkage and selection operator (LASSO) model selection was employed to classify nADrp from ADrp (classifier 1) or MCI from AD (classifier 2). Classifier 1 that discriminates nADrp from ADrp achieves high performance, with area under the curve (AUC) of the receiver operating characteristics (ROC) of 0.84 in the independent hold-out cross-sectional dataset. High performance was also seen in external testing datasets for classifier 1 (AUC of 0.70 to 0.96). Classifier 2 that discriminates MCI from AD achieves AUC of 0.79 in the independent hold-out dataset and moderate to good performance in the external testing datasets (AUC of 0.56 to 0.93). The new data analysis methods, trained on 3T data, demonstrate potential for aiding AD early detection and disease progression on both 3T and 1.5T scanners.
Article Details
Authors (204)
Xingfeng Li
Andrea G. Rockall
Paul Edison
Michael W. Weiner
Paul Aisen
Clifford R. Jack
William Jagust
Susan Landau
Monica Rivera-Mindt
Ozioma Okonkwo
Leslie M. Shaw
Edward B. Lee
Arthur W. Toga
Laurel Beckett
Danielle Harvey
Robert C. Green
Andrew J. Saykin
Kwangsik Nho
Richard J. Perrin
Duygu Tosun
Rachel Nosheny
Melanie J. Miller
Catherine Conti
Winnie Kwang
Chengshi Jin
Adam Diaz
Miriam Ashford
Derek Flenniken
Adrienne Kormos
Michael Rafii
Rema Raman
Gustavo Jimenez
Michael Donohue
Jennifer Salazar
Andrea Fidell
Virginia Boatwright
Justin Robison
Caileigh Zimmerman
Yuliana Cabrera
Karen Crawford
Scott Neu
Naomi Saito
Hannatu Amaza
Matt Glittenberg
Isabella Hoang
Kaori Kubo Germano
Joe Strong
Joel Felmlee
Nick C. Fox
Paul Thompson
Charles DeCarli
Arvin Forghanian-Arani
Bret Borowski
Calvin Reyes
Chad Ward
Robert A. Koeppe
Gil Rabinovici
Victor Villemagne
Brian LoPresti
John C. Morris
Erin Franklin
Haley Bernhardt
Nigel J. Cairns
Lisa Taylor-Reinwald
Virginia M. Y. Lee
Magdalena Korecka
Magdalena Brylska
Yang Wan
National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine
J. Q. Trojanowski
Tatiana M. Foroud
Shannon L. Risacher
Hannah Craft
Liana G. Apostolova
Kaci Lacy
Rima Kaddurah-Daouk
Li Shen
David Soleimani-Meigooni
Renaud La Joie
Konstantinos Chiotis
Charles Windon
Julien Lagarde
Jason Karlawish
Claire Erickson
Joshua Grill
Emily Largent
Kristin Harkins
Leon Thal
Zaven Khachaturian
Richard Frank
Peter J. Snyder
Neil Buckholtz
John K. Hsiao
Laurie Ryan
Susan Molchan
Maria Carrillo
William Potter
Lisa Barnes
Marie Bernard
Hector González
Carole Ho
Jonathan Jackson
Eliezer Masliah
Donna Masterman
Nina Silverberg
Lisa Silbert
Jeffrey Kaye
Sylvia White
Aimee Pierce
Amy Thomas
Tera Clay
Daniel Schwartz
Gillian Devereux
Janet Taylor
Jennifer Ryan
Mike Nguyen
Yanan Shang
Lon S. Schneider
Cynthia Munoz
Carlota Conant
Katherin Martin
Kristin O’Leary
Sonia Pawluczyk
Elizabeth Trejo
Karen Dagerman
Mauricio Becerra
Julia Boudreau
James Brewer
Antonio Gama
Jennifer Frascino
Judith Heidebrink
Ronald Petersen
Bradley Boeve
David Jones
David Knopman
Hugo Botha
Jonathan Graff-Radford
Val Lowe
Sudha Seshadri
William Hu
Jacobo Mintzer
Christopher Fowler
Stephanie R. Rainey-Smith
Sabine Bird
Julia Bomke
Pierrick Bourgeat
Belinda M. Brown
Samantha C. Burnham
Ashley I. Bush
Carolyn Chadunow
Steven Collins
James Doecke
Vincent Doré
Kathryn A. Ellis
Lis Evered
Amir Fazlollahi
Jurgen Fripp
Samantha L. Gardener
Simon Gibson
Robert Grenfell
Elise Harrison
Richard Head
Liang Jin
Adrian Kamer
Fiona Lamb
Nicola T. Lautenschlager
Simon M. Laws
Qiao-Xin Li
Lucy Lim
Yen Ying Lim
Andrea Louey
S. Lance Macaulay
Lucy Mackintosh
Ralph N. Martins
Paul Maruff
Colin L. Masters
Simon McBride
Lidija Milicic
Madeline Peretti
Kelly Pertile
Tenielle Porter
Morgan Radler
Alan Rembach
Joanne Robertson
Mark Rodrigues
Christopher C. Rowe
Rebecca Rumble
Olivier Salvado
Greg Savage
Brendan Silbert
Magdalene Soh
Hamid R. Sohrabi
Kevin Taddei
Tania Taddei
Christine Thai
Brett Trounson
Regan Tyrrell
Michael Vacher
Shiji Varghese
Victor L. Villemagne
Michael Weinborn
Michael Woodward
Computational Physics and Methods Group (CCS-2)
Ying Xia
Department of Materials Science and Engineering
David Ames
Eric O. Aboagye