A change in the cell wall status initiates the elimination of the nucellus in <i>Arabidopsis</i>

M Miryam Iannaccone (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) W Wenjia Xu (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) D Dennys-Marcela Gomez-Paez (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) S Sandrine Choinard (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) E Elisa Maricchiolo (Section of Biological and Biotechnological Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo) A Alexis Peaucelle (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) A Aline Voxeur (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) K Kalina Tamara Haas (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) C Catherine Lapierre (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay) J Jose M. Jiménez-Gómez (Centro de Biotecnología y Genómica de Plantas) A Andrea Pompa (Section of Biological and Biotechnological Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo) E Enrico Magnani (Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay)

Abstract

The evolution of the seed habit can be traced back to a change in the cell fate of the nucellus, the sporophytic tissue responsible for female meiosis. Seeds arose when the nucellus retained the female spores instead of releasing them into the environment. As a consequence, the nucellus was partially eliminated to accommodate the growth of the female gametophyte inside the sporophyte. With the evolution of angiosperm seeds, the process of nucellus elimination was requisitioned to allow the growth of the endosperm, the fertilization product devoted to storing nutrients that are at the foundation of the human diet. Cell elimination differs from most known cell death programs as it leads to the apparent dismantling of the cell wall. Here, we show that nucellus elimination in Arabidopsis is initiated by demethylesterification and subsequent lysis of the pectic polysaccharides in the cell wall. This process exposes other cell wall components to possible further degradation and precedes a cell death program that leads to nuclear DNA fragmentation. Both pathways are regulated by TRANSPARENT TESTA 16, a MADS-domain transcription factor that evolved with seed plants. Our results highlight a convergence in the structure and function of extracellular polysaccharides in animals and plants and emphasize their crucial contribution to the development of multicellular organisms.

Article Details

Volume / Issue Vol. 123, Issue 19
Published May 12, 2026
ISSN 0027-8424
Publisher National Academy of Sciences

Authors (12)

M

Miryam Iannaccone

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

W

Wenjia Xu

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

D

Dennys-Marcela Gomez-Paez

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

S

Sandrine Choinard

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

E

Elisa Maricchiolo

Section of Biological and Biotechnological Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo

A

Alexis Peaucelle

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

A

Aline Voxeur

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

K

Kalina Tamara Haas

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

C

Catherine Lapierre

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay

J

Jose M. Jiménez-Gómez

Centro de Biotecnología y Genómica de Plantas

A

Andrea Pompa

Section of Biological and Biotechnological Sciences, Department of Biomolecular Sciences, University of Urbino Carlo Bo

E

Enrico Magnani

Institut Jean-Pierre Bourgin, Institut National de Rrecherche pour l’Agriculture, l’Alimentation et l’Environnement, AgroParisTech, CNRS, University of Paris-Saclay