A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

Shihong Zhang; Tzu-Hao Tang; Sinéad Kinsella; Francesco Mazziotta; Michael T. Schweizer; Megan S. McAfee; Ariunaa Munkhbat; Yapeng Su; Valentin Voillet; Lauren E. Martin; Colton W. Smith; Yuta Asano; Menna Hailemariam; Jakob Bakhtiari; Bo Lee; Cecilia Yeung; Hung Chen; Alessandro M. Rizzi; Daniel G. Chen; Kelsey Furiya; Nick Horst; Tianzi Zhang; Phung Le; Kelly McKenna; Shannon K. Oda; Anthony Rongvaux; Phillip D. Greenberg; Thomas M. Schmitt; Aude G. Chapuis

doi:10.1038/s41467-025-67446-5

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

S Shihong Zhang T Tzu-Hao Tang S Sinéad Kinsella F Francesco Mazziotta M Michael T. Schweizer M Megan S. McAfee A Ariunaa Munkhbat Y Yapeng Su V Valentin Voillet (Cape Town HIV Vaccine Trials Network Immunology Laboratory, Hutchinson Centre Research Institute of South Africa) L Lauren E. Martin C Colton W. Smith Y Yuta Asano M Menna Hailemariam J Jakob Bakhtiari B Bo Lee C Cecilia Yeung H Hung Chen A Alessandro M. Rizzi D Daniel G. Chen K Kelsey Furiya N Nick Horst T Tianzi Zhang P Phung Le K Kelly McKenna S Shannon K. Oda A Anthony Rongvaux (Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center) P Phillip D. Greenberg T Thomas M. Schmitt A Aude G. Chapuis

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 03, 2026

DOI 10.1038/s41467-025-67446-5

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (29)

S

Shihong Zhang

T

Tzu-Hao Tang

S

Sinéad Kinsella

F

Francesco Mazziotta

M

Michael T. Schweizer

M

Megan S. McAfee

A

Ariunaa Munkhbat

Y

Yapeng Su

V

Valentin Voillet

Cape Town HIV Vaccine Trials Network Immunology Laboratory, Hutchinson Centre Research Institute of South Africa

L

Lauren E. Martin

C

Colton W. Smith

Y

Yuta Asano

M

Menna Hailemariam

J

Jakob Bakhtiari

B

Bo Lee

C

Cecilia Yeung

H

Hung Chen

A

Alessandro M. Rizzi

D

Daniel G. Chen

K

Kelsey Furiya

N

Nick Horst

T

Tianzi Zhang

P

Phung Le

K

Kelly McKenna

S

Shannon K. Oda

A

Anthony Rongvaux

Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center

P

Phillip D. Greenberg

T

Thomas M. Schmitt

A

Aude G. Chapuis

A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands

Article Details

Journal Info

Authors (29)

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