2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

R Roger S. Blumenthal (Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore) P Pamela B. Morris (Medical University of South Carolina, Charleston) M Mario Gaudino H Heather M. Johnson T Timothy S. Anderson V Vera A. Bittner R Ron Blankstein (Cardiovascular Imaging Program, Departments of Radiology and Medicine, Brigham and Women’s Hospital, Boston, MA (D.M.L., B.N.W., J.H., S.C., R.B., S.D., M.F.D.).) L LaPrincess C. Brewer (Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN (L.C.B.).) L Leslie Cho S Sarah D. de Ferranti E Eugenia Gianos T Ty J. Gluckman (Center for Cardiovascular Analytics, Research, and Data Science, Providence Heart Institute, Providence St. Joseph Health, Portland, OR (T.J.G.).) K Kristen F. Gradney I Ijeoma Isiadinso D Donald M. Lloyd-Jones J Joel C. Marrs S Seth S. Martin K Kellie H. McLain L Laxmi S. Mehta S Samia Mora W Wudeneh M. Mulugeta P Pradeep Natarajan A Ann Marie Navar C Carl E. Orringer T Tamar S. Polonsky H Harmony R. Reynolds J Joseph J. Saseen M Michael D. Shapiro D Daniel E. Soffer S Sheila A. Tynes C Chloé D. Villavaso S Salim S. Virani J John T. Wilkins A Anand Rohatgi S Samuel M. Kim K Karen P. Alexander C Cheryl Anderson C Catherine P. Benziger D Dave L. Dixon (ACC/AHA Joint Committee on Clinical Practice Guidelines liaison.) D Daniel Duprez K Keith C. Ferdinand A Anne Carol Goldberg P Parag Joshi J Joshua W. Knowles C Carl (Chip) J. Lavie Jr J Jane A. Linderbaum J John William McEvoy A Anurag Mehta C C. Noel Bairey Merz V Vijay Nambi A Ariela R. Orkaby J Jessica M. Peña, R Robert Rosenson J Janelle Ruisinger S Sigrid E. Sandner S Stacey L. Schott L Laurence (Larry) Sperling N Neil J. Stone P Peter Toth A Adam L. Ware S Seamus Paul Whelton J James Young (Department of Neurology, Icahn School of Medicine at Mount Sinai)

Abstract

AIM The “2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia” retires and replaces the “2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol.” METHODS A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).

Article Details

Journal Circulation
Volume / Issue Vol. 153, Issue 17
Published April 28, 2026
ISSN 0009-7322
Publisher Lippincott Williams & Wilkins

Journal Info

Circulation

Lippincott Williams & Wilkins

ISSN: 0009-7322 Health Sciences

Authors (62)

R

Roger S. Blumenthal

Johns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Baltimore

P

Pamela B. Morris

Medical University of South Carolina, Charleston

M

Mario Gaudino

H

Heather M. Johnson

T

Timothy S. Anderson

V

Vera A. Bittner

R

Ron Blankstein

Cardiovascular Imaging Program, Departments of Radiology and Medicine, Brigham and Women’s Hospital, Boston, MA (D.M.L., B.N.W., J.H., S.C., R.B., S.D., M.F.D.).

L

LaPrincess C. Brewer

Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN (L.C.B.).

L

Leslie Cho

S

Sarah D. de Ferranti

E

Eugenia Gianos

T

Ty J. Gluckman

Center for Cardiovascular Analytics, Research, and Data Science, Providence Heart Institute, Providence St. Joseph Health, Portland, OR (T.J.G.).

K

Kristen F. Gradney

I

Ijeoma Isiadinso

D

Donald M. Lloyd-Jones

J

Joel C. Marrs

S

Seth S. Martin

K

Kellie H. McLain

L

Laxmi S. Mehta

S

Samia Mora

W

Wudeneh M. Mulugeta

P

Pradeep Natarajan

A

Ann Marie Navar

C

Carl E. Orringer

T

Tamar S. Polonsky

H

Harmony R. Reynolds

J

Joseph J. Saseen

M

Michael D. Shapiro

D

Daniel E. Soffer

S

Sheila A. Tynes

C

Chloé D. Villavaso

S

Salim S. Virani

J

John T. Wilkins

A

Anand Rohatgi

S

Samuel M. Kim

K

Karen P. Alexander

C

Cheryl Anderson

C

Catherine P. Benziger

D

Dave L. Dixon

ACC/AHA Joint Committee on Clinical Practice Guidelines liaison.

D

Daniel Duprez

K

Keith C. Ferdinand

A

Anne Carol Goldberg

P

Parag Joshi

J

Joshua W. Knowles

C

Carl (Chip) J. Lavie Jr

J

Jane A. Linderbaum

J

John William McEvoy

A

Anurag Mehta

C

C. Noel Bairey Merz

V

Vijay Nambi

A

Ariela R. Orkaby

J

Jessica M. Peña,

R

Robert Rosenson

J

Janelle Ruisinger

S

Sigrid E. Sandner

S

Stacey L. Schott

L

Laurence (Larry) Sperling

N

Neil J. Stone

P

Peter Toth

A

Adam L. Ware

S

Seamus Paul Whelton

J

James Young

Department of Neurology, Icahn School of Medicine at Mount Sinai