The changing landscape of medicinal chemistry optimization - Anita Rácz; Levente M. Mihalovits; Maximilian Beckers; Nikolas Fechner; Nikolaus Stiefl; Finton Sirockin; William McCoull; Emma Evertsson; Malin Lemurell; Gergely Makara; György M. Keserű (Nature Reviews Drug Discovery, 2025)