Kobayashi, T., Yamazawa, T., Kurebayashi, N., Konishi, M., Tanihata, J., Sugihara, M., Miki, Y., Noguchi, S., Inoue, Y. U., Inoue, T., Sakurai, T., Murayama, T. (2025). RyR1-mediated Ca 2+ -induced Ca 2+ release plays a negligible role in excitation–contraction coupling of normal skeletal muscle. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2500449122