Parsons, A. M., Byrne, S., Kooistra, J., Dewey, J., Zebolsky, A. L., Alvarado, G., Bouma, G. J., Heuvel, G. B. V., Larson, E. D. (2025). G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD. Nature Communications. https://doi.org/10.1038/s41467-024-55684-y