Sun, R., Jiang, P., Wang, Z., Yan, B., Zhu, S., Huang, Z., Zhang, J., Ding, D., Li, X., Wang, L., Lou, Z., Jin, B., Pang, J., Huang, H., Xia, D. (2025). DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2413732122